1 Principles of Drug Therapy Dawn Merton Boothe Chapter Outline DOSE–RESPONSE RELATIONSHIP DETERMINANTS OF DRUG DISPOSITION Mechanisms of Drug Movement Plasma Drug Concentrations Enantiomers and Drug Disposition FIXED DOSING REGIMENS…
Table 7-11 Classification of Beta-Lactamases, the Enzymes, and Drugs Targeted5,37 Chapter 7 Antimicrobial Drugs Dawn Merton Boothe Chapter Outline DRUGS THAT TARGET THE CELL WALL Beta-Lactam Antimicrobials Vancomycin Teicoplanin Fosfomycin…
Chapter 14 Therapy of Cardiovascular Diseases Dawn Merton Boothe Chapter Outline CARDIOVASCULAR PHYSIOLOGY AS IT PERTAINS TO CARDIOVASCULAR DRUGS Membrane Ion Movements and the Action Potential Afterload and Preload Myocardial…
Chapter 19 Gastrointestinal Pharmacology Dawn Merton Boothe Chapter Outline DRUGS THAT TARGET APPETITE OR CALORIC BALANCE APPETITE STIMULANTS Cachexia APPETITE SUPPRESSANTS AND ANTI-OBESITY DRUGS EMETICS AND ANTIEMETICS The Vomiting Reflex…
Chapter 29 Antiinflammatory Drugs Dawn Merton Boothe Chapter Outline THE PATHOPHYSIOLOGY OF INFLAMMATION THE ROLE OF CHEMICAL MEDIATORS IN THE INFLAMMATORY RESPONSE SHARED PHARMACOLOGY OF NONSTEROIDAL ANTIINFLAMMATORY DRUGS Chemistry Mechanism…
Table 28-4 Pharmacokinetic Data for Selected Opioids in Dogs or Cats∗227 AUC, Area under the curve; Vdss, volume of distribution at steady state; CL, clearance; MRT, mean residence time; F,…
Table 6-4 Integration of Population Pharmacodynamic (PD) and Pharmacokinetic (PK) Data and Its Role in the Design of Dosing Regimens 6 Principles of Antimicrobial Therapy∗ Dawn Merton Boothe Chapter Outline…
Chapter 20 Drugs Affecting the Respiratory System Dawn Merton Boothe Chapter Outline NORMAL RESPIRATORY PHYSIOLOGY Airway Caliber Changes Respiratory Defense Mechanisms SURFACTANT PATHOGENESIS OF INFLAMMATORY RESPIRATORY DISEASES INFLAMMATORY MEDIATORS IN…
Table 27-2 Indications for Anticonvulsants in Humans Based on Seizural Activity Chapter 27 Anticonvulsants and Other Neurologic Therapies in Small Animals Dawn Merton Boothe Chapter Outline PHYSIOLOGY AND SEIZURE PATHOPHYSIOLOGY…
Chapter 16 Fluids, Electrolytes, and Acid–Base Therapy Reid P. Groman, Michael D. Willard Chapter Outline PHYSIOLOGY Water Sodium Potassium Acid–Base Balance DISEASE-INDUCED CHANGES Sodium Chloride Potassium Miscellaneous Minerals Acid–Base Status…
