Pharmacokinetics
3 Pharmacokinetics Jim E. Riviere Pharmacokinetics is best defined as the use of mathematical models to quantitate the time course of drug absorption and disposition in man and animals. With…
Antiprotozoan Drugs
42 Antiprotozoan Drugs Jennifer L. Davis and Jody L. Gookin Numerous chemotherapeutic agents are known to possess activity against parasitic protozoa (Tables 42.1 and 42.2). Although antiprotozoal activity is characteristic…
Principles of Acid–Base Balance: Fluid and Electrolyte Therapy, Blood Substitutes
23 Principles of Acid–Base Balance: Fluid and Electrolyte Therapy, Blood Substitutes Maya M. Scott-Garrard, Melisa Rosenthal, and Deborah T. Kochevar Composition and Distribution of Body Fluids Units of Measure The units…
Absorption, Distribution, Metabolism, and Elimination
2 Absorption, Distribution, Metabolism, and Elimination Jim E. Riviere The four key physiological processes that govern the time course of drug fate in the body are absorption, distribution, metabolism, and…
Mechanism of Drug Action and Pharmacokinetics/Pharmacodynamics Integration in Dosage Regimen Optimization for Veterinary Medicine
4 Mechanism of Drug Action and Pharmacokinetics/Pharmacodynamics Integration in Dosage Regimen Optimization for Veterinary Medicine Pierre-Louis Toutain Introduction Pharmacokinetics (PK) studies the fate of drugs in the animal whereas pharmacodynamics…