, J. David Jentsch2 and Marie-FranÇoise Chesselet1 (1) Department of Neurology, The David Geffen School of Medicine at UCLA, Los Angeles, CA, USA (2) Department of Psychology, The David Geffen School of Medicine…
(1) Department of Genetics, Case Western Reserve University, Cleveland, OH, USA Abstract Animal models of disease in genetically manipulated mice are powerful tools in medical research, including the study…
and Peter Sandøe2 (1) Laboratory Animal Science, IBMC – Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal (2) Danish Centre for Bioethics and Risk Assessment, Faculty of Life…
(1) Center for Aging/Division of Geriatrics, Duke University Medical Center, Durham, NC, USA Abstract Producing a valid animal model of apolipoprotein E (APOE )-based dementia is critical to understanding…
and James A. RogersIII2 (1) Office of Intellectual Property, Mayo Clinic, Rochester, MN, USA (2) Legal Department, Mayo Clinic, Rochester, MN, USA James A. RogersIII Email: sstoddard@mayo.edu Abstract Transgenic mouse models of…
and Akihiko Takashima1 (1) Lab. for Alzheimer’s Disease, RIKEN Brain Science Institute, Saitama, Japan Abstract Since the identification of the mutations in presenilin 1 and presenilin 2 genes more than…
2. Guénette SY, Tanzi RE (1999) Progress toward valid transgenic mouse models for Alzheimer’s disease. Neurobiol Aging 20:201–211.PubMedCrossRef 3. Sturchler-Pierrat C, Abramowski D, Duke M et al (1997) Two amyloid…
(1) Department of Experimental Psychology, University of Oxford, Oxford, UK Abstract The search for a good animal, preferably mouse, model of Alzheimer’s disease (AD) is one of the most…
and Deborah Young2 (1) Department of Molecular Medicine & Pathology,Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand (2) Department of Pharmacology & Clinical Pharmacology,Faculty of Medical…
and Maria Cristina Rosi1 (1) Department of Preclinical and Clinical Pharmacology, University of Florence, Florence, Italy Abstract The neurochemical alterations underlying the cognitive and behavioral symptoms that constitute the clinical picture…
