APP-Based Transgenic Models: The PDAPP Model
and David M. Holtzman1 (1) Department of Neurology, Washington University School of Medicine, St. Louis, MO, Washington, USA Abstract The PDAPP mouse has been a very useful model for studying mechanisms…
Caenorhabditis elegans as a Model Organism for Dementia
and Ellen A. A. Nollen1 (1) Department of Genetics, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands Abstract The free living nematode worm Caenorhabditis elegans (C. elegans) has been extensively…
Pathological Validation of Animal Models of Dementia
, Christine Van Broeckhoven1 and Samir Kumar-Singh1 (1) Neurodegenerative Brain Diseases Group, VIB Department of Molecular Genetics and Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Wilrijk, Belgium (2) Department of Histology, University…
The 3xTg-AD Mouse Model: Reproducing and Modulating Plaque and Tangle Pathology
, Masashi Kitazawa1 and Frank LaFerla1 (1) Department of Neurobiology and Behavior Institute for Brain Aging and Dementia, University of California, Irvine, CA, USA Abstract Alzheimer’s disease (AD) is a devastating…
Animal Models of Alcohol-Induced Dementia
and Silvia R. Castanheira Pereira1 (1) Laboratório de Neurociência Comportamental e Molecular – LaNeC, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil Abstract Alcoholic dementia is a disorder characterized by multiple cognitive…
Animal Models of Metallic Dementia
(1) Division of Human Anatomy, Department of Biomedical Sciences and Biotechnology, Faculty of Medicine, University of Brescia, Brescia, Italy Abstract Alzheimer’s disease (AD) is nowadays the most widespread form…
CADASIL: Molecular Mechanisms and Animal Models
(1) Center for Biomedical Genomics & Informatics, Department of Molecular & Microbiology, George Mason University, Manassas, VA, USA Abstract Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL)…
Animal Models of Frontotemporal Dementia
and Daniel T. Laskowitz1 (1) Division of Neurology, Duke University, Durham, NC, USA Abstract Frontotemporal dementia (FTD) is a multifaceted syndrome with a high degree of clinical and neuropathological variability, an…
Animal Models of Amyotrophic Lateral Sclerosis
(1) Laboratory of Neurobiology, Leuven, Belgium Abstract Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by the selective death of motor neurons. Although ALS is predominantly a disease…
Mouse Models of Metachromatic Leukodystrophy and Adrenoleukodystrophy
, Caroline Sevin1 and Nathalie Cartier1 (1) Faculté des Sciences Pharmaceutiques et Biologiques-Paris5, INSERM UMR745 and Paris-Descartes University, Paris, France Abstract Metachromatic leukodystrophy (MLD) and adrenoleukodystrophy (ALD) are two inherited leukodystrophies…
