Emma L. Lane and Stephen B. Dunnett (eds.)NeuromethodsAnimal Models of Movement Disorders1Volume I10.1007/978-1-61779-298-4_1© Springer Science+Business Media, LLC 2011 1. Why Cannot a Rodent Be More Like a Man? A Clinical Perspective Anne E. Rosser1 (1) The Brain…
2. Langston JW, Ballard P, Tetrud JW, Irwin I. (1983) Chronic parkinsonism in humans due to a product of meperidine-analog synthesis. Science 219:979–80PubMedCrossRef 3. Petzinger GM, Jakowec MW. (2004) The…
Fig. 1. (a) During a chronic treatment period with daily injections of l-DOPA at low doses, the rodents will gradually develop abnormal involuntary movements, reaching a plateau after 10–14 days…
Emma L. Lane and Stephen B. Dunnett (eds.)NeuromethodsAnimal Models of Movement Disorders1Volume I10.1007/978-1-61779-298-4_16© Springer Science+Business Media, LLC 2011 16. Of Rats and Patients: Some Thoughts About Why Rats Turn in Circles and Parkinson’s Disease Patients…
Fig. 1. Preparations used for electrophysiological recordings. Schematic representation of some of the most common electrophysiological techniques. Top left: Acutely dissociated neuron with two recording electrodes and sample traces of…
A. Recurrent episodes of binge eating. An episode of binge eating is characterized by both of the following: 1. Eating, in a discrete period of time (e.g., within any 2-h…
Selection criterion (High vs. low vulnerability) Drug-related behavior Drug/reinforcer Reference Novel environment reactivity(HR vs. LR) Drug-induced locomotor activity (HR > LR) Amphetamine (27) Morphine (28) Self-administration (HR > LR) Amphetamine…
Fig. 1. An anorectic anx/anx mouse and a +/+ mouse, age 17 days. 2.2 Genetics The anx mutation arose spontaneously in the second filial generation (F2) of a cross between…
Fig. 1. (a) Mean ± SEM rates of agonistic behavior for animals categorized as dominant (ranked 1 and 2) and subordinate (ranks 3 thru 5). Dominant females receive less aggressive…
Fig. 1. The stressful procedure: rats were prevented from accessing HPF, but were able to see and smell it. In this 15 min period, rats engaged in repeated movements of…
