Molecular genetic testing and karyotyping in the horse
The ISAG Panel defines the minimum number of markers to be used for horse identification and parentage analysis. In practice, panels in current usage contain 17–20 markers. Such panels have…
Genomics of muscle disorders
Eventual sequencing of the GBE1 gene coding sequences resulted in the discovery of a mutation in exon 1 that results in a premature stop codon (Ward et al., 2004). GBED was…
The Y-Chromosome
The horse Y chromosome varies considerably (more than twice as compared to the smallest known size) in length among normal individuals (Hansen, 1984; Power, 1988; our unpublished observations). This polymorphism…
Genomics of reproduction and fertility
Genetics of mare fertility After REEL and gonadal dysgenesis that are caused by chromosomal abnormalities, the most common subfertile phenotype in mares is the failure to become pregnant (Coutinho da…
Genomics of performance
Mitochondrial DNA and Athletic Performance in Thoroughbreds In 2006, Harrison and Turrion-Gomez reported a relationship between mitochondrial DNA (mtDNA) haplotypes and athletic performance in the Thoroughbred (Harrison & Turrion-Gomez, 2006)….
Physical and comparative maps
The horse karyotype Ever since the correct chromosome number in the horse was determined, the equine chromosomes have been presented in several ways. However, it was not before the correct…
Genomics of laminitis
Molecular biology has been crucial in refuting a central dogma in equine laminitis and in organ injury in human sepsis, stating that laminar/organ injury was due to decreased blood flow,…
Functional genomics
Functional Impact of the Genome Genomic DNA contains the “informational blueprint” of an organism, which has now been elucidated in the horse by sequencing of the equine genome (Wade et al.,…
Defining the equine genome: The nuclear genome and the mitochondrial genome
Application of different banding techniques A variety of staining/banding techniques have been applied to analyze equine chromosomes. The ultimate goal of using these banding techniques was to exploit a range…
Genetics of equine neurologic disease
There is an association with a vitamin E deficiency in cases of NAD/EDM, although low vitamin E levels are not present consistently in all cases. It appears that vitamin E…
