Contusion Models of Spinal Cord Injury in Rats
Clinical features Injury type Gross features Histological features Clinical frequency (%) Chapter Animal models Solid Cord Injury Normal Demyelination, motor neuron loss 10 Felts et al., ch. 19 None…
Assessing Spinal Cord Injury
Fig. 1. Ground reaction forces produced by rats moving along a runway. (a) Rats are conditioned to move repeatedly along a runway in which three force platforms (plates 1–3) are…
Excitotoxic Lesions of the Rodent Striatum
Target protein or molecule Target cells Reason NeuN Mature neurones To visualise loss of striatal neurones Cresyl violet or Nissl stain All cells To visualise the cell loss DARPP-32 Striatal…
The Role of the Pedunculopontine Tegmental Nucleus in Motor Disorders
Fig. 1. Illustration of the location, connections and composition of the PPTg. (a) Sagittal view on a rat brain section (taken from the atlas of Paxinos and Watson (94)). Schematic…
Demyelination Models in the Spinal Cord
Fig. 1. Light micrographs of toluidine blue-stained sections showing regions of the spinal cord of a female DA rat following induction of active EAE using whole spinal cord homogenate as…
Genetic Models of Cerebellar Dysfunction
Mutants Ataxic or not Stationary beam Suspended string Inclined grid Rotorod References Grid2 Lc Ataxic ↓ ↓ ↓ ↓ (78, 79) Grid2 ho-Nancy Ataxic ↓ ↓ ? ↓ (14, 79,…
Behavioral Assessment of Genetic Mouse Models of Huntington’s Disease
Fig. 1. Climbing activity in C57Bl/6J mice at 6.5 weeks of age. Mice were tested either during dark phase, or light phase (not both). Mice climb more during their active…
3-Nitropropionic Acid and Other Metabolic Toxin Lesions of the Striatum
2. Shoulson I, Asbury A, McKhann GM, McDonald I (1986) Huntington’s Disease: The disease of the nervous system. Ardmore Medical Books (W. B. Saunders): Philadephia 3. Maragos WF, Young KL,…
Combination Lesion Models of MSA
Fig. 1. Lesion models. Illustration of the conditions of the rodent brains, in particular the striatum and substantia nigra, in healthy unlesioned animals (a) and the different lesion paradigms (b–h)….
Models of Rodent Cortical Traumatic Brain Injury
2. Finfer SR, Cohen J (2001) Severe traumatic brain injury. Resuscitation 48: 77–90PubMed 3. Thurman DJ, Alverson C, Dunn KA, Guerrero J, Sniezek JE (1999) Traumatic brain injury in the…
