of High-Grade Gliomas: Preclinical In Vivo Experiments in Animal Models
, Bryan D. Choi2 and Duane A. Mitchell3 (1) Department of Pathology, Duke University Medical Center, Durham, NC, USA (2) Duke Brain Tumor Immunotherapy Program, Division of Neurosurgery, Department of Surgery and Department of…
Models in Cancer Research: Assessment of Severity and the Application of Humane Endpoints
Total severity score Actions to take for the different level of severity Severity level 0 No action to be taken because animal is normal Mild 1–5 Monitor more closely Mild…
Tumor Models to Predict Clinical Outcome: Like the Phoenix?
Fig. 1. A long chain of events. This depicts the chain of events from tumor initiation through the final effects of tumor therapy, for both primary brain tumors and brain…
About Retinoblastoma from Mouse Models That Missed
2. Albert DM (1987) Historic review of retinoblastoma. Ophthalmology 94:654–662PubMed 3. Weller CV (1941) The inheritance of retinoblastoma and its relationship to practical eugenics. Cancer Res 1:517–535 4. Knudson AG…
