Physical and comparative maps
The horse karyotype Ever since the correct chromosome number in the horse was determined, the equine chromosomes have been presented in several ways. However, it was not before the correct…
Genomics of laminitis
Molecular biology has been crucial in refuting a central dogma in equine laminitis and in organ injury in human sepsis, stating that laminar/organ injury was due to decreased blood flow,…
Functional genomics
Functional Impact of the Genome Genomic DNA contains the “informational blueprint” of an organism, which has now been elucidated in the horse by sequencing of the equine genome (Wade et al.,…
Defining the equine genome: The nuclear genome and the mitochondrial genome
Application of different banding techniques A variety of staining/banding techniques have been applied to analyze equine chromosomes. The ultimate goal of using these banding techniques was to exploit a range…
Genetics of equine neurologic disease
There is an association with a vitamin E deficiency in cases of NAD/EDM, although low vitamin E levels are not present consistently in all cases. It appears that vitamin E…
Coat color genomics
Cream (C) is inherited as an incompletely dominant gene. In the heterozygous condition cream dilutes phaeomelanin from red to yellow, which results in palominos, buckskins, and smoky seal browns. Homozygotes…
Genomics of skin disorders
Noticeable lesions indicative of the disease generally appear at approximately 1.5 years of age (White et al., 2004; White et al., 2007). This means that HERDA-affected horses rarely show signs at birth…
Genomic tools and resources: Development and applications of an equine SNP genotyping array
Utility of the Beadchip for Mapping Simple Traits within Breeds As a proof of principle, mapping of three known coat color loci – the recessive chestnut coat color (MC1R) (Marklund,…
Mitochondrial genome: Clues about the evolution of extant equids and genomic diversity of horse breeds
For instance, the Bayesian analysis of the mtDNA data combined partial sequences from three regions: D loop, 12S rRNA, and Cytb (2074 bp total; Figure 19.1a) from Genbank and recently…
Unexpected structural features of the equine major histocompatibility complex
In many ways, the alignment of ELA sequence with HLA demonstrated a great deal of organizational similarity and conserved synteny as expected (Gustafson et al., 2003). Sequence alignments also confirmed earlier…
