and Daniel T. Laskowitz1 (1) Division of Neurology, Duke University, Durham, NC, USA Abstract Frontotemporal dementia (FTD) is a multifaceted syndrome with a high degree of clinical and neuropathological variability, an…
(1) Laboratory of Neurobiology, Leuven, Belgium Abstract Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by the selective death of motor neurons. Although ALS is predominantly a disease…
, Caroline Sevin1 and Nathalie Cartier1 (1) Faculté des Sciences Pharmaceutiques et Biologiques-Paris5, INSERM UMR745 and Paris-Descartes University, Paris, France Abstract Metachromatic leukodystrophy (MLD) and adrenoleukodystrophy (ALD) are two inherited leukodystrophies…
, J. David Jentsch2 and Marie-FranÇoise Chesselet1 (1) Department of Neurology, The David Geffen School of Medicine at UCLA, Los Angeles, CA, USA (2) Department of Psychology, The David Geffen School of Medicine…
(1) Department of Genetics, Case Western Reserve University, Cleveland, OH, USA Abstract Animal models of disease in genetically manipulated mice are powerful tools in medical research, including the study…
and Peter Sandøe2 (1) Laboratory Animal Science, IBMC – Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal (2) Danish Centre for Bioethics and Risk Assessment, Faculty of Life…
(1) Center for Aging/Division of Geriatrics, Duke University Medical Center, Durham, NC, USA Abstract Producing a valid animal model of apolipoprotein E (APOE )-based dementia is critical to understanding…
and James A. RogersIII2 (1) Office of Intellectual Property, Mayo Clinic, Rochester, MN, USA (2) Legal Department, Mayo Clinic, Rochester, MN, USA James A. RogersIII Email: sstoddard@mayo.edu Abstract Transgenic mouse models of…
and Akihiko Takashima1 (1) Lab. for Alzheimer’s Disease, RIKEN Brain Science Institute, Saitama, Japan Abstract Since the identification of the mutations in presenilin 1 and presenilin 2 genes more than…
2. Guénette SY, Tanzi RE (1999) Progress toward valid transgenic mouse models for Alzheimer’s disease. Neurobiol Aging 20:201–211.PubMedCrossRef 3. Sturchler-Pierrat C, Abramowski D, Duke M et al (1997) Two amyloid…
