Advanced Diagnostic Techniques
CHAPTER 17 Advanced Diagnostic Techniques José A. Ramos-Vara, Anne C. Avery, Paul R. Avery Cytopathology is a highly useful, noninvasive method for diagnosis of malignant vs. benign conditions and identification…
Musculoskeletal System
CHAPTER 13 Musculoskeletal System Anne M. Barger Lameness is the cardinal clinical sign associated with disease of the musculoskeletal system. Other signs include stiffness, ataxia, weakness, pain, fever, limb and…
Endocrine System
CHAPTER 16 Endocrine System A. Rick Alleman, Ul Soo Choi The endocrine system consists of the thyroid, parathyroid, adrenal cortex, and pancreatic islet cells. These highly integrated, highly vascularized glands…
The Acquisition and Management of Cytology Specimens
CHAPTER 1 The Acquisition and Management of Cytology Specimens Denny J. Meyer, Sara L. Connolly, Hock Gan Heng The classification of events that depend on the accuracy of observation is…
Gestational MAM (Methylazoxymethanol) Administration: A Promising Animal Model for Psychosis Onset
Fig. 2.1. Spontaneous locomotor activity in prenatal E17 MAM- vs. saline-exposed rats. Total distance (±SEM) travelled by sham and MAM-exposed rats during a 60-min testing period in the open field…
A Method to the Madness: Producing the Neonatal Ventral Hippocampal Lesion Rat Model of Schizophrenia
Fig. 1.1. The modified Eppendorf tubes are prepared for use for IBO storage by taking one Eppendorf tube, cutting the lower half off and stuffing it into another Eppendorf. 2.3…
The Hypoxic Rat Model for Obstetric Complications in Schizophrenia
Fig. 4.1. Risk genes and environmental factors such as hypoxia play a role in the pathophysiology of schizophrenia during the perinatal period, whereas symptoms occur in young adulthood after the…
Studying Schizophrenia in a Dish: Use of Primary Neuronal Cultures to Study the Long-Term Effects of NMDA Receptor Antagonists on Parvalbumin-Positive Fast-Spiking Interneurons
Fig. 6.1. Development of PV-synaptic contacts in primary neurons cultured from cortical tissue. Cultured cortical neurons were immunostained for simultaneous detection of αCaMKII (left panel: glutamatergic neuron) and parvalbumin (right…
Psychiatric Genetics and the Generation of Mutant Animal Models
Fig. 8.1. Genetic architecture of common psychiatric disorders. Based on current findings, genetic variants that are relatively common in the population (>5%) have minimal impact on disease risk with most…
The Developmental Vitamin D (DVD) Model of Schizophrenia
Fig. 5.1. Time taken to deplete a female Sprague–Dawley rat of 25OHD3 (•) compared with a control dam (∘) over the same pre-breeding period (mean ± SD). After 6 weeks…
