Coat color genomics
Cream (C) is inherited as an incompletely dominant gene. In the heterozygous condition cream dilutes phaeomelanin from red to yellow, which results in palominos, buckskins, and smoky seal browns. Homozygotes…
Genomics of skin disorders
Noticeable lesions indicative of the disease generally appear at approximately 1.5 years of age (White et al., 2004; White et al., 2007). This means that HERDA-affected horses rarely show signs at birth…
Genomic tools and resources: Development and applications of an equine SNP genotyping array
Utility of the Beadchip for Mapping Simple Traits within Breeds As a proof of principle, mapping of three known coat color loci – the recessive chestnut coat color (MC1R) (Marklund,…
Mitochondrial genome: Clues about the evolution of extant equids and genomic diversity of horse breeds
For instance, the Bayesian analysis of the mtDNA data combined partial sequences from three regions: D loop, 12S rRNA, and Cytb (2074 bp total; Figure 19.1a) from Genbank and recently…
Unexpected structural features of the equine major histocompatibility complex
In many ways, the alignment of ELA sequence with HLA demonstrated a great deal of organizational similarity and conserved synteny as expected (Gustafson et al., 2003). Sequence alignments also confirmed earlier…
Genomics of skeletal disorders
Genetic analyses among foals at an age between 4 and 9 months and in 2-year-old horses demonstrated genetic correlations between the signs for osteochondrotic lesions in foals and OCD (joint…
Assembly and analysis of the equine genome sequence
Another common practice among those who sequence and assemble genomes is to make use of animals that have high homozygosity. The reason that this is desirable is to minimize the…
Disorders of the Pelvic Limb: Diagnosis and Treatment
Summary Orthopedic conditions of the pelvic limb are some of the most frequently diagnosed causes of lameness in the dog. In the sporting dog as well as the active companion,…
Disorders of the Canine Forelimb: Veterinary Diagnosis and Treatment
Summary Shoulder conditions are common causes of forelimb lameness in dogs, particularly performance dogs. Given the intricacy of shoulder motion and the stress placed on the shoulder joint for routine…
Conditioning and Retraining the Canine Athlete
Summary Exercise has significant physical and psychological benefits for dogs. One of the most important is extension of healthspan, the length of time that a dog remains healthy and active….
