Fig. 2.1. Spontaneous locomotor activity in prenatal E17 MAM- vs. saline-exposed rats. Total distance (±SEM) travelled by sham and MAM-exposed rats during a 60-min testing period in the open field…
Fig. 1.1. The modified Eppendorf tubes are prepared for use for IBO storage by taking one Eppendorf tube, cutting the lower half off and stuffing it into another Eppendorf. 2.3…
Fig. 4.1. Risk genes and environmental factors such as hypoxia play a role in the pathophysiology of schizophrenia during the perinatal period, whereas symptoms occur in young adulthood after the…
Fig. 6.1. Development of PV-synaptic contacts in primary neurons cultured from cortical tissue. Cultured cortical neurons were immunostained for simultaneous detection of αCaMKII (left panel: glutamatergic neuron) and parvalbumin (right…
Fig. 8.1. Genetic architecture of common psychiatric disorders. Based on current findings, genetic variants that are relatively common in the population (>5%) have minimal impact on disease risk with most…
Fig. 7.1. Synthesis and role of glutathione (GSH). (a) GSH synthesis requires two ATP-dependent enzymatic steps. The first and rate-limiting enzyme is GCL that binds glutamate (Glu) and cysteine (Cys)…
Fig. 5.1. Time taken to deplete a female Sprague–Dawley rat of 25OHD3 (•) compared with a control dam (∘) over the same pre-breeding period (mean ± SD). After 6 weeks…
Fig. 11.1. l-Methionine (MET) decreases spine density on both the apical and the basilar dendrites. Mean spine density ±SE shown here for a distance of 50–100 μm from the pyramidal cell…
Model Approach Function Construct Expression pattern Gross anatomy Cellular abnormalities Behavior Significance Kamiya In utero E14.5 KD function of endogenous Disc1 Disc1 RNAi or express C-terminally truncated DISC1 Pyramidal cortical…
4. Brown, A. S., Schaefer, C. A., Quesenberry, C. P., Jr., Liu, L., Babulas, V. P., and Susser, E. S. (2005) Maternal exposure to toxoplasmosis and risk of schizophrenia in…
