MRI of Neurological Damage in Rats and Mice
Fig. 1. Animal cradle for fixation in the MRI system. The half-pipe cradle (centre of the figure) holds the animal laid in prone position over the bed with the circulating…
6-OHDA Lesion Models of Parkinson’s Disease in the Rat
Fig. 1. Ten-microlitre microsyringe setup for MFB lesion injections. The 30-gauge cannula is connected to the needle of the syringe using polythene tubing. The syringe, tubing and cannula are filled…
Comparing Behavioral Assessment of Sensorimotor Function in Rat and Mouse Models of Parkinson’s Disease and Stroke
Emma L. Lane and Stephen B. Dunnett (eds.)NeuromethodsAnimal Models of Movement Disorders1Volume I10.1007/978-1-61779-298-4_17© Springer Science+Business Media, LLC 2011 17. Comparing Behavioral Assessment of Sensorimotor Function in Rat and Mouse Models of Parkinson’s Disease and Stroke…
6-OHDA Toxin Model in Mouse
Conc. (μg/μl)a Volume (μl) Stereotaxic co-ordinates (mm)b Strain Sex Reference 16 4 n/r n/r M (31) 4 4 AP = +5 (to occipital structure), ML = −2.2, DV = −3.5…
Zebrafish as a Vertebrate Model Organism for Studying Movement Disorders
Fig. 1. A schematic drawing of the telencephalon of ray-finned fish illustrating the subdivisions of the telencephalon (left) in a coronal section. On the right is a presentation of how…
The MPTP-Treated Primate, with Specific Reference to the Use of the Common Marmoset (Callithrix jacchus)
Common name Scientific classification New world primates Common marmoset Calithrix jacchus Squirrel monkey Saimiri sciureus Capuchin Cebus apella Owl monkey Aotus trivirgatus Old world primates Cynomolgus Macaca fascicularis Rhesus Macaca…
Why Cannot a Rodent Be More Like a Man? A Clinical Perspective
Emma L. Lane and Stephen B. Dunnett (eds.)NeuromethodsAnimal Models of Movement Disorders1Volume I10.1007/978-1-61779-298-4_1© Springer Science+Business Media, LLC 2011 1. Why Cannot a Rodent Be More Like a Man? A Clinical Perspective Anne E. Rosser1 (1) The Brain…
Using the MPTP Mouse Model to Understand Neuroplasticity: A New Therapeutic Target for Parkinson’s Disease?
2. Langston JW, Ballard P, Tetrud JW, Irwin I. (1983) Chronic parkinsonism in humans due to a product of meperidine-analog synthesis. Science 219:979–80PubMedCrossRef 3. Petzinger GM, Jakowec MW. (2004) The…
Rodent Models of l-DOPA-Induced Dyskinesia
Fig. 1. (a) During a chronic treatment period with daily injections of l-DOPA at low doses, the rodents will gradually develop abnormal involuntary movements, reaching a plateau after 10–14 days…
Of Rats and Patients: Some Thoughts About Why Rats Turn in Circles and Parkinson’s Disease Patients Cannot Move Normally
Emma L. Lane and Stephen B. Dunnett (eds.)NeuromethodsAnimal Models of Movement Disorders1Volume I10.1007/978-1-61779-298-4_16© Springer Science+Business Media, LLC 2011 16. Of Rats and Patients: Some Thoughts About Why Rats Turn in Circles and Parkinson’s Disease Patients…
