Fig. 4.1. Risk genes and environmental factors such as hypoxia play a role in the pathophysiology of schizophrenia during the perinatal period, whereas symptoms occur in young adulthood after the…

Fig. 6.1. Development of PV-synaptic contacts in primary neurons cultured from cortical tissue. Cultured cortical neurons were immunostained for simultaneous detection of αCaMKII (left panel: glutamatergic neuron) and parvalbumin (right…

Fig. 8.1. Genetic architecture of common psychiatric disorders. Based on current findings, genetic variants that are relatively common in the population (>5%) have minimal impact on disease risk with most…

Fig. 7.1. Synthesis and role of glutathione (GSH). (a) GSH synthesis requires two ATP-dependent enzymatic steps. The first and rate-limiting enzyme is GCL that binds glutamate (Glu) and cysteine (Cys)…

Fig. 5.1. Time taken to deplete a female Sprague–Dawley rat of 25OHD3 (•) compared with a control dam (∘) over the same pre-breeding period (mean ± SD). After 6 weeks…

Fig. 11.1. l-Methionine (MET) decreases spine density on both the apical and the basilar dendrites. Mean spine density ±SE shown here for a distance of 50–100 μm from the pyramidal cell…