Reflexes and motor systems

Chapter 5 Reflexes and motor systems





Key points




image A reflex is a stereotypical somatic or autonomic activity triggered by a specific stimulus. The reflex arc involves sensory input, connection in the CNS to the UMN, the LMN, neuromuscular junction and muscle.


image Muscle tone and bulk depends on LMN function.


image UMNs initiate, regulate, modify and terminate the activity of the LMN. UMNs may inhibit or facilitate LMNs. Loss of inhibitory UMN function results in increased muscle tone and spinal reflexes, whereas loss of facilitatory UMNs results in paresis or paralysis.


image The UMN system originating from the motor cortex is responsible for voluntary and learned movement of the face, body and limbs using the corticonuclear and corticospinal/pyramidal tracts, respectively. It is more important in primates and humans than quadrupeds.


image The extrapyramidal system is responsible for maintaining posture and rhythmical/semiautomatic activities including locomotion. Extrapyramidal UMN tracts originate primarily in the brainstem and their fibres do not travel in the pyramids. In quadrupeds, this system is of primary importance.


image Specific UMN tracts are excitatory or inhibitory to LMNs. Movement is ultimately expressed through the LMNs stimulating muscles.


image Loss of UMN input typically results in paresis or paralysis with normal to increased muscle tone and spinal reflexes caudal to the lesion. Muscle atrophy is mild and due to disuse.


image Loss of the LMNs results in paresis/paralysis, with decreased to absent muscle tone and reflexes. Muscle atrophy can be severe and is neurogenic in origin.


image The ‘Neuro RAT’ helps differentiate between UMN and LMN signs – Reflexes, Atrophy and Tone.


image Planning of motor activity takes place in the forebrain and motor function is modulated by input from the cerebellum and basal nuclei.



General introduction


Normal posture, gait and voluntary movement require input from sensory systems, planning and coordination centres, storage (memory) areas, and output through motor systems using UMNs and LMNs. Upper motor neurons are the ‘managers’ and are confined to the CNS. Lower motor neurons are the ‘workers’ and have their nerve cell body in the CNS, but the axon, which forms the majority of the cell, travels via spinal or cranial nerves in the PNS to synapse at the neuromuscular junction. Thus we suggest that motor neurons could be described as either UMNs / central motor neurons, which are managers; and LMNs / peripheral motor neurons, which are workers. In the case of the autonomic efferent fibres, there are a pre-synaptic and a post-synaptic LMN (peripheral motor neuron). The terms central and peripheral motor neurons are more descriptive than upper motor neuron and lower motor neuron, however UMN and LMN are widely used, despite their propensity to cause significant confusion.


The strength of muscle contraction is directly proportional to the frequency of action potentials in the nerve supplying the muscle. Conversely, the precision of muscle function is inversely proportional to the size of the motor unit, where a motor unit is defined as a single α-LMN axon and the muscle fibres with which it synapses. Muscles with large motor units, such as proximal limb muscles, are used for imprecise movements. Small motor units, such as found in the extraocular muscles, enable fine, specific movement of the target organ, such as the eye.


Muscle activity for maintaining posture (at rest or during motion) arises largely at a subconscious/subcortical level, whereas voluntary movement arises primarily from a conscious/cortical level. The subconscious level utilises reflex arcs linking function within, and between, limbs. Subcortical control results in postural changes (sitting, standing, etc.) and repetitive movement, such as breathing, basic locomotion, scratching and chewing.


Cerebrocortical control is used for voluntary, complex and learned movements such as hunting or the pet offering its paw to be shaken. Primates and humans have a much greater dependence on cortical motor centres of the forebrain for all movement including gait. In comparison, the spinal reflexes in domestic mammals, are the basic functional unit that underpins all posture and locomotion on which is superimposed, supraspinal input originating largely in the brainstem. As such, forebrain lesions can result in hemiparesis/plegia in humans, but do not compromise significantly locomotion in domestic mammals.



Spinal reflexes




A reflex is defined as a stereotypical response produced by a specific stimulus. The reflex arc involves receptors and nerves of the PNS (sensory and motor) and a region of the CNS in which the sensory input connects to the motor output. This CNS region is in the brain for cranial nerve reflexes and in the spinal cord for limb and body reflexes. Reflexes are ‘hard-wired’, meaning that the neuronal connections are established during embryonic development and are present at birth. Conversely, neural responses (e.g. the menace response) have to be learned. Their ‘wiring’ develops postnatally as a consequence of experience. The reflex is the functional unit of the nervous system as compared with the morphological unit that is the neuron.


That the reflex is the most basic functional unit of the nervous system is evidenced by its presence in simple metazoan animals. In vertebrates, incoming sensory input into the dorsal horn can synapse directly with LMNs in the ventral horn of that spinal cord segment and stimulate a motor output. This simplest reflex is called a monosynaptic reflex and is exemplified by the patellar reflex. Most other reflexes involve interneurons interposed between the input and output side. Interneurons permit divergence (see Fig. 4.9) so that the input can be distributed to a wider population of output neurons. Thus one type of input can stimulate both agonist muscle contraction and antagonist muscle relaxation, e.g. the patellar reflex can stimulate quadriceps muscle contraction and hamstring muscle relaxation (see Fig. 4.4).


There are a number of different types of reflexes including:



Reflex arcs can be ipsilateral, contralateral due to decussation of the fibres, intrasegmental located within one spinal cord segment, or intersegmental involving a number of different spinal cord segments.



Muscle spindles


Muscle spindles are spindle/fusiform-shaped receptors located within striated/skeletal muscles. They are called stretch receptors as they detect stretching of the muscle. Muscle spindles comprise modified muscle cells called intrafusal fibres that have contractile elements at the ends of the spindle and sensory receptors in the middle. The surrounding normal muscle fibres are referred to as extrafusal. Muscle spindles are located in parallel with the extrafusal muscle fibres and, consequently, are stretched when the muscle is stretched. The contractile elements of muscle spindles are innervated by γ-motor neurons that, when stimulated, cause contraction at the ends of the spindle, thus stretching the centre of the spindle. The intrafusal fibres and the γ-motor neuron comprise the fusimotor system. Stretching of the muscle spindle causes firing of the sensory receptors in the spindle and stimulation of the 1a afferent nerve fibres. Sensory impulses travel via the spinal nerve to the spinal cord, or, if arising from head muscles, via cranial nerves to the brainstem. In the CNS the 1a afferent fibre synapses with α-LMNs resulting in stimulation of extrafusal fibres and muscle contraction. The extrafusal fibre plus the α-LMN is the skeletomotor system (Fig. 5.1).




The myotatic reflex


The myotatic (‘stretch’) reflex arc is a feature of limb and trunk muscles especially. It uses the stimulus of muscle stretching to generate nerve impulses in the 1a afferent fibre. The impulses travel to the spinal cord, synapse (usually via interneurons) onto the α-LMN supplying that same muscle, stimulating nerve impulses in that α-LMN. This causes contraction of the extrafusal fibres surrounding the muscle spindle, thereby shortening the muscle and reducing the stretch of the muscle spindle. Thus, activity in the 1a afferent nerve fibre stimulates agonist muscle contraction. Simultaneously, it also causes reciprocal inhibition; that is, it inhibits contraction in the antagonist muscle. For example, the effect of gravity on the weight-bearing stifle joint is to make it collapse (stifle flexion), thereby stretching the quadriceps muscle and its muscle spindles. Spindle stretching causes reflex contraction of the quadriceps muscle and stifle extension to support the animal’s weight. Simultaneously, the stifle flexors (hamstring muscles such as the semimembranosus and semitendinosus muscles) will be inhibited. The input from the 1a afferent is also forwarded to the brain to provide proprioceptive information that is essential for planned and coordinated motor function (see Chapter 6).


Different types of 1a fibres are stimulated by static versus dynamic stretching. Stretching of the muscle spindle and stimulation of 1a afferents can be caused by the following.



Within the spinal cord the input from the 1a afferent fibres can link to LMNs in the same spinal cord segment or in different spinal cord segments, ipsi- or contralaterally (see Fig. 4.8). The propriospinal tract is a white matter tract immediately surrounding the grey matter of the spinal cord, and conveys axons connecting between spinal cord segments. Thus input from one muscle can influence other muscles acting around that joint, or other joints in the same limb, or other limbs. For example, in the withdrawal reflex, noxious stimulation of the foot causes limb flexion. If the animal is standing at the time, then the other limbs will extend to compensate for the loss of weight-bearing in the stimulated limb. The withdrawal reflex uses multiple spinal cord segments to activate both multiple flexor muscles within the stimulated limb, and extensor muscles of the other limbs.




α-γ co-activation


When the α-LMNs are stimulated, the extrafusal fibres contract, reducing the stretch of the intrafusal fibres; this decreases activation of the Ia afferent fibre. This decreased sensory input to the CNS would result in loss of proprioceptive input (Chapter 6). But if the γ-LMN is activated simultaneously with the α-LMN, then the intrafusal fibres contract, causing comparable shortening of the muscle spindle. Thus the relative stretch of the muscle spindle is maintained and the Ia firing is sustained. Therefore when a muscle is stimulated to contract, both α- and γ-LMNs are simultaneously stimulated and proprioceptive input from the muscle about its length and tension is maintained. This is called α-γ co-activation. Functionally, this acts to maintain appropriate muscle tone, despite changes in muscle length, and to maintain continual proprioceptive input to brain, which is essential for normal posture and movement.




Posture and the myotatic reflex


The myotatic reflex is reflex activity based on muscle spindle input. It is a major mechanism by which the animal maintains posture and supports itself against gravity. Gravity acts on the animal to cause flexion/collapse of the limb joints, flexion of the cervical vertebral column due to the weight of the head and extension (lordosis) of the thoracolumbar vertebral column due to the weight of the trunk. Thus gravity causes stretching of the muscle spindles in the extensor muscles of the limbs and neck, and flexor muscles of the thoracolumbar vertebral column. The stretching causes firing of the 1a sensory fibres from the spindles, input via the spinal nerves to the spinal cord, stimulation of the α-LMNs and extension of the limbs and neck and flexion of the vertebral column. Simultaneously, the antagonistic muscles (limb and neck flexors and spinal extensors) may be inhibited (Fig. 5.2).


Stay updated, free articles. Join our Telegram channel

Aug 26, 2016 | Posted by in INTERNAL MEDICINE | Comments Off on Reflexes and motor systems

Full access? Get Clinical Tree

Get Clinical Tree app for offline access