Ascending somatic sensory tracts and conscious sensory systems

Chapter 6 Ascending somatic sensory tracts and conscious sensory systems





A wide variety of sensory modalities are projected to the cerebral cortex. The stimuli are collected by a plethora of sensory receptors that are classified as exteroceptors, interoceptors and proprioceptors.



Receptors


Animals have a variety of receptor types that detect different stimuli (thermal, mechanical, chemical and photo stimuli); receptors detect changes in both the animal’s external and internal environments.


Receptors may be encapsulated in connective tissue or non-encapsulated and have bare dendrites. They are designed to respond preferentially to a certain type of stimulus, but will usually respond to several different forms of energy. Regardless of stimulus type, it is transduced as an electrical impulse.


Exteroceptors are activated by stimuli in the immediate external environment such as temperature and touch. They include both encapsulated (Pacinian corpuscles and Ruffini endings) and free nerve endings that respond to pressure, vibration and distortion of the tissue. They may adapt to a constant stimulus either rapidly or slowly. Exteroceptors also include those receptors concerned with special sensations, such as audition, vision and gustation (taste) (see Chapter 10).


Interoceptors detect the internal, visceral environment of the body. Conscious perception of the viscera is mainly via nociceptors, which are stimulated by distension of visceral walls or ischaemia.


Proprioceptors include receptors such as the muscle spindle fibres and Golgi tendon organs located in muscles, tendons or joints and also tactile/pressure receptors. They detect muscle stretch, tension, position and movement of body parts.


Nocioceptors respond to many types of stimuli but have a high threshold; that is the stimulus must be of sufficient intensity to cause tissue destruction.


Pathway: Most conscious sensory systems share a common format that comprises a three-stage system:



Sensory modalities that do not fit this three-stage structure include olfaction, vision and some nociceptive pathways (Table 6.1).


Table 6.1 Ascending tracts, their functions and locations in the spinal cord































































Modality Tract Location
Nociception Fasciculus gracilis and fasciculus cuneatus (skin) DF
Spinocervicothalamic tract (skin) LF
Spinothalamic tract (skin, viscera and body) LF
Spinoreticular tract (viscera and body) VF
Spinomesencephalic tract VF
Temperature Spinothalamic tract (viscera and body) LF
Discriminative touch, pressure and conscious proprioception Fasciculus cuneatus (from the body cranial to T8) DF
Fasciculus gracilis and dorsal spinocerebellar tract (from the body caudal to T8) DF
Arousal and behaviour Spinothalamic tract LF
Spinoreticular tract VF
Spinomesencephalic tract VF
Subconscious proprioception and cerebellar input Dorsal and ventral spinocerebellar tract (from the caudal half of body) LF
Spinocuneocerebellar and cranial spinocerebellar tracts (from the cranial half of body) DF and LF, respectively
Spinoreticular tract VF
Spinopontine tract VF
Spinovestibular (from the neck) VF
Spino-olivary tract VF

DF = dorsal funiculus, LF = lateral funiculus, VF = ventral funiculus.


See also Fig. 2.5.



General proprioception


Proprioception (proprius – L = one’s own, capere – L = to receive) is the sense of the relative position of parts of the body. Proprioception indicates whether and how joints, muscles and tendons are moving based on input from muscle spindles, Golgi tendon organs and joint receptors. It also indicates where various parts of the body are located in relation to each other. Tactile and mechanoreceptors, especially on the feet, contribute to proprioception, especially conscious proprioception, while hair cells in the vestibular apparatus of the inner ear supply information about head position and movement.


Proprioceptive information from peripheral receptors travels via spinal nerves, the dorsal roots and spinal cord (dorsal and lateral funiculi) to the brain (Fig. 6.1). Proprioception of the head, its muscles and joints, uses mainly cranial nerves VIII and V to reach the appropriate brainstem nuclei. The information that terminates in the somatosensory cortex of contralateral cerebrum is used in conscious proprioception while that terminating in the ipsilateral cerebellum is used in subconscious proprioception. Conscious proprioception is the conscious awareness of body position and movement of body parts. It enables the cerebral cortex to plan and refine voluntary, learned movements. Subconscious proprioception is based around stretch and tension of muscles, tendons and ligaments, at rest and during movement, and spatial orientation of the body. The cerebellum needs this information to coordinate posture and locomotion. The vestibular system provides proprioceptive information (conscious and subconscious) about head position and movement. This input is fundamental for setting the balance and posture of the whole animal.



Subconscious proprioception from the head (vestibular input), body and limbs (spinal input) is essential for normal posture and gait. Subconscious proprioceptive deficits result in the clinical sign of ataxia. Ataxia can be defined functionally as incoordinated movement. It presents as changes in the rate, range and force of movement. Ataxia does not mean that the animal is paretic (weak), however, cases of spinal cord disease may often present with both ataxia and UMN paresis due to compression of general proprioceptive and UMN tracts.


Both conscious and subconscious proprioceptive systems are essential for normal posture and gait and it can be difficult to rigorously separate conscious from subconscious proprioceptive deficits when presented with an ataxic patient. However in dogs and cats, subconscious proprioceptive deficits usually perturb posture and gait more than conscious proprioceptive deficits. This is evidenced by observing the effect of lesions located at the termination of subconscious versus conscious proprioceptive pathways. For example, ataxia is more pronounced with lesions in the cerebellum than lesions affecting the somatosensory cortex in the forebrain. Subconscious proprioceptive deficits due to cerebellar lesions may present with truncal sway, base wide or narrow posture and limb movement, and delays in initiating or terminating movement. In dogs and cats with lesions affecting the somatosensory cortex where conscious proprioceptive pathways terminate, only mild stumbling, or a tendency to stand on the dorsum of the paw, may be observed. Gait and posture may otherwise be reasonably normal.



Conscious proprioception




Non-painful, conscious sensations can broadly be divided into two categories that share functional and anatomical features. One group comprises touch and pressure, and the other is composed of joint and muscle/tendon proprioception. Both are principally transmitted to the cerebral cortex via the dorsal column–medial lemniscal system involving primarily the dorsal funiculus of the spinal cord with some transmission in the lateral funiculus (see Fig. 4.5). The dorsal funiculus is also known as the dorsal column and it continues as the medial lemniscus in the brainstem.


Axons conveying this information enter the dorsal funiculus and join the fasciculus cuneatus (from the body cranial to T8) or fasciculus gracilis (caudal to T8). Fibres in the fasciculus cuneatus convey proprioceptive and discriminative touch. They synapse in the medial cuneate nucleus located in the caudal medulla oblongata (see Figs. A26–30). Only about one-quarter of the fasciculus gracilis fibres synapse in the nucleus gracilis in the medulla oblongata. Thus the dorsal funiculus is relatively unimportant in transmitting proprioception from the pelvic limbs in quadrupeds; it is important in humans. The majority of fibres entering the fasciculus gracilis leave it in the cranial lumbar region to synapse in the grey matter on interneurons, or relay neurons of other pathways, or even LMNs. Fibres arising from synapses at the base of the dorsal horn (e.g. the nucleus thoracicus (see Table 4.2) may continue cranially in the dorsal spinocerebellar tract (with collateral fibres travelling in the adjacent spinomedullary tract) to synapse near the nucleus gracilis (in nucleus Z) (Figs. A24, A27, A28). Post-synaptic fibres from these proprioceptive relay nuclei (gracile, medial cuneate and Z) decussate in the deep arcuate fibres of the medulla oblongata and continue rostrally in the medial lemniscus to the thalamus where they synapse. They are projected to the somatosensory cortex of the cerebrum via the internal capsule.


The role of the lateral funiculus in conveying pelvic limb proprioception to the cerebrum may be one explanation why cervical spinal cord compression can produce particularly marked pelvic limb ataxia. This is illustrated in Fig. 6.3 on ‘Wobbler’ horses and dogs (see accompanying text).


The dorsal column–medial lemniscal system is highly organised topographically and is quite specific with respect to the transmission of sensory and discriminatory information. In other words, there is little convergence (input) of other pathways onto the relay nuclei; this enables the animal to localise precisely a stimulus from the skin, e.g. the horse biting at a fly on its body. Similarly, the somatosensory cortex is somatopically arranged and the size of each area reflects the density of innervation (see Fig. 4.14).


The dorsal funiculus comprises a greater percentage of white matter in carnivores and primates than in other animals; this reflects higher sensory discrimination from the digits, especially compared with ungulates.


There are two kinds of proprioceptive input from the head – that associated with head position and movement (see Chapter 8) and proprioception due to receptors associated with muscles of mastication, facial expression and eye movement. Muscle proprioception is also conveyed by a three-neuron system via all three branches of CN V (trigeminal nerve). The trigeminal ganglion at the base of the neurocranium is the equivalent of a spinal ganglion, containing somatosensory neuronal cell bodies. However, uniquely, the cell bodies of the primary afferent neurons concerned with muscle proprioception are found in the CNS, in the mesencephalic nucleus of V. The second stage fibres decussate, travel rostrally in the trigeminal lemniscus to the thalamus and on to the somatosensory cortex. The proprioceptive fibres in the mesencephalic nucleus of CN V also connect to other cranial nerve motor nuclei for reflex function. Sensory fibres from tongue musculature (intrinsic and extrinsic) have their cell bodies located in the trigeminal, C1 and distal vagal ganglia.

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Aug 26, 2016 | Posted by in INTERNAL MEDICINE | Comments Off on Ascending somatic sensory tracts and conscious sensory systems

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