Chapter 163 In idiopathic EBP, a dominant helper T cell type 2 (TH2) immune response is suspected, based on a selective increase in CD4+ T cells in bronchoalveolar lavage fluid (BALF) (Clercx et al, 2002) and increased levels of messenger RNA encoding for eotaxins, the strongest chemoattractants for eosinophils, in bronchial biopsy specimens from dogs with EBP (Peeters et al, 2006). The cause of these changes is unknown. A limited number of positive intradermal skin test reactions have been described in affected dogs; however, the relationship between positive intradermal skin test results and detection of aeroallergens responsible for EBP is still unclear. Lower airway and pulmonary destruction and remodeling observed in canine EBP may be connected to up-regulation of collagenolysis, related perhaps to increased activity of matrix metalloproteinase 8 (MMP-8), MMP-9, and MMP-13 (Rajamaki et al, 2002). Figure 163-1 Endoscopic view of the bronchi of a 5-year-old female rottweiler with eosinophilic bronchopneumopathy showing a large amount of sticky yellow material (A) and bronchiectasis with the presence of almost solid material (B).
Eosinophilic Pulmonary Diseases
Pathogenesis
Diagnosis
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Eosinophilic Pulmonary Diseases
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