G. Diane Shelton,     La Jolla, California

Diagnosis of Myasthenia Gravis

The spectrum of clinical presentations in both cats and dogs is broad and variable; thus autoimmune MG should be high on the list of differential diagnoses for any dog or cat with focal or generalized neuromuscular weakness, acquired megaesophagus, or dysphagia. In-depth discussions of the diversity of clinical presentations in canine and feline MG can be found in the literature (Dewey et al, 1997; Shelton, 2002; Shelton, Ho, and Kass, 2000; Shelton and Lindstrom, 2001; Shelton, Schule, and Kass, 1997). The onset of clinical signs commonly is acute, occurring only a few days to a few weeks before presentation. Because of the propensity of dogs with MG to develop aspiration pneumonia, autoimmune MG is one disease in which a delay in obtaining a diagnosis or assumption of the wrong diagnosis can result in a fatal outcome.

When MG is suspected, ideally a serum sample should be collected for acetylcholine receptor (AChR) antibody testing and the diagnosis confirmed before initiation of therapy. The gold standard for the diagnosis of autoimmune MG continues to be the demonstration of autoantibodies against muscle AChRs by immunoprecipitation radioimmunoassay. The assay is specific and sensitive and documents an autoimmune response against muscle AChRs. Although seronegative MG occurs in approximately 2% of dogs with generalized MG, false-positive results are rare.

The edrophonium chloride challenge test (Tensilon or Enlon, 0.1 to 0.2 mg/kg in dogs and 0.25 to 0.5 mg total dose in cats IV) also should be performed since dramatic positive test results give a presumptive diagnosis of MG and allow initiation of therapy before serologic confirmation. A negative edrophonium chloride challenge result does not rule out a diagnosis of MG. In addition, a subjective improvement in muscle strength may be found in other neuromuscular diseases; thus, unless the response is dramatic, the edrophonium chloride challenge test should not be used alone to confirm a diagnosis.

Treatment of Focal and Generalized Myasthenia Gravis

No single treatment regimen is ideal for all cases of MG. Choices must be made among the therapeutic options, with the goal of obtaining the best result while keeping the risks and adverse effects as low as possible. Each case needs an individualized treatment plan, which may have to be changed from time to time depending on the stage of the disease and response to treatments. Relative to discussion of available treatments, autoimmune MG can be divided into focal (group 1), generalized (group 2), acute fulminating (group 3), and paraneoplastic (group 4) forms. Unlike humans with MG, in whom treatment is usually lifelong, dogs with MG routinely experience spontaneous remission if they survive the initial month following onset of clinical signs and do not have a thymoma (Shelton and Lindstrom, 2001).