CHAPTER 117 Regional Limb Perfusion with Antimicrobials
The aim in treating orthopedic infections and infected limb wounds in horses is eradication of bacterial load, removal of foreign material, elimination of inflammatory mediators and free radicals, pain relief, and restoration of the normal environment to promote tissue healing. The goal of antimicrobial therapy is to achieve antimicrobial concentrations above the minimum inhibitory concentration (MIC) in the infected tissue without inducing toxic effects in the animal. This can be accomplished by systemic and local administration of antimicrobial agents.
Box 117-1 Antimicrobial Doses Commonly Administered by Regional Limb Perfusion
Drug | Dose |
---|---|
Gentamycin | 100 mg–1 g |
Amikacin | 125 mg–1 g |
Ampicillin | 9 g |
Timentin |