Web Chapter 34 A commercial polymerase chain reaction (PCR)–based method for MDR1 genotyping using canine DNA from mouth cells is available for detecting the mutation in dogs and should be considered if ivermectin must be used in potentially susceptible breeds. Information is available at the Washington State University Veterinary Clinical Pharmacology Laboratory website (www.vetmed.wsu.edu/depts-VCPL/test.aspx). A rapid PCR- based method that can discriminate between homozygous and heterozygous alleles using a small amount of genomic DNA from a blood sample also is available commercially (Geyer et al, 2005).
Avermectins in Dermatology
Avermectins
Ivermectin
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