The dysphagic/gagging/regurgitating cancer patient

8 The dysphagic/gagging/regurgitating cancer patient

Dysphagia is defined as painful or difficult swallowing and can usually be subclassified as oral dysphagia, pharyngeal dysphagia and cricopharyngeal dysphagia. Dysphagia, therefore, generally refers to pathology within the oral cavity and/or the pharyngeal region. Gagging is defined as the reflex part of swallowing/vomiting, involving elevation of the soft palate followed by reverse peristalsis of the upper gastrointestinal tract and it is often accompanied by retching, which is the involuntary and ineffective attempt to vomit. Regurgitation is defined as the passive, retrograde expulsion of gastric or oesophageal contents and as such is a sign of oesophageal disease. Cancer patients with some or all of these clinical signs therefore could have neoplastic disease in one or more than one of several locations:


Theory refresher

Patients presenting with dysphagia, gagging or retching firstly require a careful history to be obtained in order to attempt to establish exactly what the clinical sign(s) is (are). Oral dysphagia may present as difficulty prehending the food, or as an abnormal movement when swallowing, such as a head tilt or a more violent ‘head-throwing’ action as if to force the food down, whilst patients with pharyngeal dysphagia often prehend their food normally but then exhibit frequent attempts to swallow, often expressed as frequent flexing and stretching of the neck. Once the presenting problem and history have been established, a careful clinical examination is essential. This should include a thorough neurological evaluation to identify any neuropathy or neuromuscular pathology. Careful visual examination of the oral cavity and oro-pharynx is also required, which may necessitate the use of sedation or even a brief general anaesthetic as some tonsillar tumours will be painful. The aims of the clinical examination are to identify: (a) the primary disease location if possible, (b) the extent of any disease process, (c) the presence of any complicating secondary problems such as aspiration pneumonia and (d) the suitability of the patient for treatments (i.e. Are they currently too ill for major surgery? How will post-surgical nutrition be delivered?).

Tonsillar tumours can present with progressive dysphagia, inappetance, oral/pharyngeal pain, cervical swelling or possibly blood-stained hypersalivation. Diagnosis is made by direct visualization of a tonsillar mass (which often appears reddened, ulcerated and haemorrhagic) and then incisional or excisional biopsy. In the light of the risk of haemorrhage, excisional biopsy is usually considered to be best practice for this condition. Unfortunately, however, the prognosis for patients with primary tonsillar tumours is guarded. Primary tonsillar cancers in cats and dogs are almost always malignant; with squamous cell carcinoma (SCC) being the most common tumour type reported but tonsillar lymphoma has also been described. Other tumour types reported within the tonsils are metastasizing oral neoplasms, especially malignant melanoma.

Tonsillar carcinomas are usually seen in older dogs (mean age 10 years in one study, range 2–17) and are considered highly metastatic tumours, with 10–20% having pulmonary metastasis identified at initial presentation and 77% having distant metastasis identified on post-mortem. No specific breeds have been identified as having a particular predisposition to this disease but some studies have reported a significantly higher incidence of the condition in dogs living in urban environments compared to rural locations. Tonsillar carcinomas display rapid growth, significant invasion into surrounding tissues and early metastasis to regional lymph nodes and then lungs and/or other distant organs. Treatment therefore is difficult, as although tonsillectomy may help to alleviate the presenting clinical signs in the short term (and such a procedure may also be required to achieve a definitive diagnosis), it can never be considered to be a procedure undertaken with curative intent. The efficacy of tonsillectomy with postoperative radiotherapy has been studied and this approach does appear to offer better control of local spread and increases the average survival times compared to surgery alone. But the 1-year survival rates are still very low at 10% and the mean survival time reported in one study was only 151 days. Sole-agent chemotherapy does not appear to have any reasonable activity against tonsillar carcinomas. In one study, various chemotherapy combination treatments were assessed and the mean survival times were only approximately 100 days despite treatment. Combining external beam radiation therapy with chemotherapy (doxorubicin and cisplatin) does appear to generate significantly longer survival times (mean 306 days) but disease progression and the development of distant metastasis is still the major obstacle to longer-term survival times. Currently therefore, the treatment associated with the longest life expectancy for patients with carcinoma of the tonsil would be surgical excision followed by combination radiation and chemotherapy. However, in many cases, advising that no further treatment would be fair for the animal is certainly acceptable if the disease is extensive and the primary tumour is causing significant clinical problems.

Sep 10, 2016 | Posted by in SMALL ANIMAL | Comments Off on The dysphagic/gagging/regurgitating cancer patient

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