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Nephrotoxic Agents in Dogs and Cats









































Agent Comments/Notes
Aminoglycoside antibiotics like neomycin, kanamycin, gentamicin, amikacin, and tobramycin Dogs, cats; not common anymore; mostly seen with parenteral use with repeated dosing, especially if dehydration has not been corrected first
Tetracyclines Dogs; reported with intravenous use; rare
Sulfonamides Crystalluria leading to nephrotoxicity; used less commonly such that toxicity not common anymore
NSAIDs such as carprofen, deracoxib, naproxen, ibuprofen, nabumetone, ketoprofen, oxaprozin, etodolac, piroxicam, flurbiprofen, sulindac, diclofenac, meloxicam, tepoxalin Cats generally more sensitive than dogs; renal toxicosis can occur with acute single large overdose or with repeated use; adverse GI effects more common
Ethylene glycol (antifreeze) Cats more sensitive than dogs (require less amount to be toxic), but more cases seen in dogs
Melamine and cyanuric acid (contamination) Cats, dogs; outbreak in United States from contaminated dog and cat food in 2007; crystalluria, azotemia, GI signs
Grapes and raisins ingestion Dogs only; initial GI signs followed by evidence of renal damage/failure, azotemia > 24 hours
Plants: Easter lily (Lilium longiflorum), tiger lily (Lilium tigrinum), day lily (Hemerocallis spp.), rubrum or Japanese show lilies (Lilium speciosum) Cats only; initially vomiting, anorexia, and lethargy followed by evidence of renal damage within 24–72 hours
Cholecalciferol and other vitamin D3 analogs such as calcipotriene and calcitriol Dogs and cats; mostly reported in dogs; initial GI signs followed by hyperphosphatemia, hypercalcemia, azotemia, CV and CNS effects
Zinc (pennies, zinc-plated nuts, wires) Dogs; affects multiple organs; hemoglobinuria, anemia, azotemia, increased liver enzymes, pancreatitis
Heavy metals such as lead, mercury, arsenic These affect multiple organs; GI signs, CNS effects, increased liver enzymes, azotemia; profuse diarrhea and shock from arsenic

CNS, Central nervous system; CV, cardiovascular; GI, gastrointestinal; NSAIDs, nonsteroidal antiinflammatory drugs.


Adapted from Khan SA: Intoxication versus acute nontoxicologic illness: differentiating the two. In Ettinger SJ, Feldman EC, editors: Textbook of veterinary internal medicine, St Louis, 2010, Saunders, pp 549–554.



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Jul 24, 2016 | Posted by in SMALL ANIMAL | Comments Off on N

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