W Warfarin Sodium war′far-in soe′dee-um Trade and Other Names: Coumadin and generic brands Functional Classification: Anticoagulant Pharmacology and Mechanism of Action Anticoagulant. Warfarin sodium depletes vitamin K, which is responsible for generation of clotting factors. Half-life of warfarin in animals is 36-42 hours (20-30 hours in cats). Indications and Clinical Uses In small animals, it has been used to treat hypercoagulation disease and prevent thromboembolism. In horses, warfarin has been used to treat navicular disease, although it is not popular for this use. Precautionary Information Adverse Reactions and Side Effects Adverse effects are attributable to decreased blood clotting. Spontaneous bleeding can result in blood loss, hemoperitoneum, hemarthrosis, gastrointestinal bleeding, epistaxis, and excessive bleeding from trauma or surgery. Contraindications and Precautions Do not administer to animals that may be prone to bleeding. Administer carefully with other drugs that are known to interfere with coagulation. Drug Interactions Multiple drugs and some foods may affect warfarin’s action. Some of these that may potentiate warfarin’s action include aspirin, chloramphenicol, phenylbutazone, ketoconazole, and cimetidine. Drug interactions are possible with administration with other highly protein-bound drugs, but such reactions are poorly documented in animals. Drug interactions are also possible with trimethoprim sulfonamides and metronidazole. Do not administer with some cephalosporin drugs (particularly those with N-methylthiotetrazole [NMTT]) because cephalosporins may induce bleeding through anti-vitamin-K–dependent mechanisms.< div class='tao-gold-member'> Only gold members can continue reading. Log In or Register to continue Share this:Click to share on Twitter (Opens in new window)Click to share on Facebook (Opens in new window) Related Related posts: F O U That May Induce Cytochrome P-450 Enzymes Stay updated, free articles. Join our Telegram channel Join Tags: Saunders Handbook of Veterinary Drugs Small and Large Animal Jul 18, 2016 | Posted by admin in PHARMACOLOGY, TOXICOLOGY & THERAPEUTICS | Comments Off on W Full access? Get Clinical Tree
W Warfarin Sodium war′far-in soe′dee-um Trade and Other Names: Coumadin and generic brands Functional Classification: Anticoagulant Pharmacology and Mechanism of Action Anticoagulant. Warfarin sodium depletes vitamin K, which is responsible for generation of clotting factors. Half-life of warfarin in animals is 36-42 hours (20-30 hours in cats). Indications and Clinical Uses In small animals, it has been used to treat hypercoagulation disease and prevent thromboembolism. In horses, warfarin has been used to treat navicular disease, although it is not popular for this use. Precautionary Information Adverse Reactions and Side Effects Adverse effects are attributable to decreased blood clotting. Spontaneous bleeding can result in blood loss, hemoperitoneum, hemarthrosis, gastrointestinal bleeding, epistaxis, and excessive bleeding from trauma or surgery. Contraindications and Precautions Do not administer to animals that may be prone to bleeding. Administer carefully with other drugs that are known to interfere with coagulation. Drug Interactions Multiple drugs and some foods may affect warfarin’s action. Some of these that may potentiate warfarin’s action include aspirin, chloramphenicol, phenylbutazone, ketoconazole, and cimetidine. Drug interactions are possible with administration with other highly protein-bound drugs, but such reactions are poorly documented in animals. Drug interactions are also possible with trimethoprim sulfonamides and metronidazole. Do not administer with some cephalosporin drugs (particularly those with N-methylthiotetrazole [NMTT]) because cephalosporins may induce bleeding through anti-vitamin-K–dependent mechanisms.< div class='tao-gold-member'> Only gold members can continue reading. Log In or Register to continue Share this:Click to share on Twitter (Opens in new window)Click to share on Facebook (Opens in new window) Related Related posts: F O U That May Induce Cytochrome P-450 Enzymes Stay updated, free articles. Join our Telegram channel Join Tags: Saunders Handbook of Veterinary Drugs Small and Large Animal Jul 18, 2016 | Posted by admin in PHARMACOLOGY, TOXICOLOGY & THERAPEUTICS | Comments Off on W Full access? Get Clinical Tree
