Sorbitol Dehydrogenase (SDH)

Sorbitol Dehydrogenase (SDH)



Basic Information image



Definition


Leakage enzyme: Soluble cytoplasmic enzymes released into circulation after increased membrane permeability (sublethal cellular injury or cellular necrosis)



Typical Normal Range (US Units; SI Units)


1.0 to 8.0 IU/L



Physiology


Sorbitol dehydrogenase is a rapid leakage enzyme essential for carbohydrate metabolism and is specific to the liver. The degree of increase is generally proportional to the number of injured hepatocytes; very high values suggest acute hepatitis. It has a short half-life of less than 12 hours and quickly returns to normal; consistently increased values suggest ongoing and active hepatocellular damage.



Causes of Abnormally High Levels




• Marked increases in acute hepatitis (equine herpesvirus type 1, embolic bacterial diseases, Tyzzer’s disease (Clostridium piliformis), hepatotoxins, Theiler’s disease (serum hepatitis), cholangiohepatitis associated with ascending enteric bacteria, and chronic active hepatitis


• Mild to moderate increases in cholelithiasis, strangulating or obstructive gastrointestinal diseases, acute enterocolitis with endotoxemia, and hyperlipemia syndrome

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Jul 24, 2016 | Posted by in SMALL ANIMAL | Comments Off on Sorbitol Dehydrogenase (SDH)

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