Sea urchin
C. elegans
Human
N° nodes
127
100
151
N° links
175
132
202
Clustering coefficient
0.023
0.032
0.028
Diameter
23
23
20
Average n° neighbors
2.740
2.620
2.662
Characteristic path length
8.128
7.816
6.546
Most linked node
[Ca2+]i
[Ca2+]i
[Ca2+]i
N° links of most linked node
19 (14.6 %)
10 (10 %)
25 (17.1 %)
For all species, the clustering coefficient was low (0.023–0.032) and did not depend on the number of links per node (R2 always less than 0.250). The characteristic path length was always between 6.6 and 7.6. In all networks, the most linked node is the intracellular concentration of calcium [Ca2+]i. Glycolysis and mitochondrial oxidative phosphorylation were common to all tested organisms (Fig. 8.1).
