© Springer International Publishing Switzerland 2015
Peter Girman, Jan Kriz and Peter Balaz (eds.)Rat Experimental Transplantation Surgery10.1007/978-3-319-14559-4_77. Recovery After Surgery
(1)
Laboratory of Pancreatic Islets, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
(2)
Pancreatic Islet Laboratory, Diabetes Center, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
Abstract
Postoperative care should be considered an important and integral part of the experimental study, which can dramatically impact the outcome of the surgery. Any surgical procedure is not complete until the animal is fully conscious and self-sufficient in accessing water and food. Especially in case of multiple surgeries performed sequentially, it is useful to have the assistant providing surveillance over the animal during the early post-op period. Most operating rules prohibit the return of animal to the animal facility until it is fully recovered. Postoperative management includes cage for recovery, maintenance of body temperature, fluid and nutritional support, pain management and eye protection.
Keywords
RecoveryPain managementSurveillancePost-operative monitoringTemperature maintenancePostoperative care should be considered an important and integral part of the experimental study. Any surgical procedure is not complete until the animal is fully conscious and self-sufficient in accessing water and food. Especially in case of multiple surgeries performed sequentially, it is useful to have the assistant providing surveillance over the animal during the early post-op period. Most operating rules prohibit the return of animal to the animal facility until it is fully recovered.
7.1 Cage for Recovery
1.
The cage should be smooth, safe and empty – without bedding and treats
2.
Uncoordinated movements of the animal during recovery can cause injury of the corneas
3.
Uncontrolled (spontaneous) swallowing can cause the injury of the tongue or induce some aspiration of small pieces of bedding
7.2 Maintenance of Body Temperature
Rodents are small animals, which have a limited capacity of thermoregulation. Commonly used anesthetics significantly impair thermoregulation during total anesthesia [1] and even more in combination with a large abdominal surgery. Therefore, hypothermia can be easily induced during the surgical procedure without any adequate thermal support. Hypothermia is a serious complication leading frequently to a critical condition or even the death of experimental animal. The reasons are:
Supportive heating can be considered a difference between the successful surgery and the failure. Hypothermia can be prevented:
1.
Preoperative: by increasing of pre-anesthetic peripheral body temperature, body condition [6]