Q

Q



Quinacrine Hydrochloride



kwin’eh-krin hye-droe-klor’ide


Trade and Other Names: Atabrine (No longer available in the US.)


Functional Classification: Antiparasitic



Pharmacology and Mechanism of Action


Antimalarial drug. Quinacrine is an outdated antimalarial drug. It inhibits nucleic acid synthesis in parasites.



Indications and Clinical Uses


Quinacrine is used occasionally for treatment of protozoa (Giardia), but other drugs (e.g., metronidazole and tinidazole) are used more often. Although it is not commercially available, veterinarians have obtained quinacrine through compounding pharmacies.



Precautionary Information



Adverse Reactions and Side Effects


Side effects are common. Vomiting occurs after oral administration.



Contraindications and Precautions


No contraindications are reported for animals.



Drug Interactions


No drug interactions have been reported in animals.



Instructions for Use


Doses listed are for treatment of giardiasis. Effects for other organisms are not reported.



Patient Monitoring and Laboratory Tests


No specific monitoring is necessary.



Formulations


Quinacrine is available in 100-mg tablets. Quinacrine may no longer be marketed in the US, but it may be available from some pharmacies in a compounded formulation.



Stability and Storage


Store in a tightly closed container, protected from light, and at room temperature. Stability of compounded formulations has not been evaluated.



Small Animal Dosage



Dogs



• 6.6 mg/kg q12h PO for 5 days.


Cats



• 11 mg/kg q24h PO for 5 days.


Large Animal Dosage


No doses have been reported for large animals.



Regulatory Information


Withdrawal times are not established for animals that produce food. For extralabel use withdrawal interval estimates, contact FARAD at 1-888-USFARAD (1-888-873-2723).

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Jul 18, 2016 | Posted by in PHARMACOLOGY, TOXICOLOGY & THERAPEUTICS | Comments Off on Q

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