Q
Quinacrine Hydrochloride
Pharmacology and Mechanism of Action
Antimalarial drug. Quinacrine is an outdated antimalarial drug. It inhibits nucleic acid synthesis in parasites.
Indications and Clinical Uses
Quinacrine is used occasionally for treatment of protozoa (Giardia), but other drugs (e.g., metronidazole and tinidazole) are used more often. Although it is not commercially available, veterinarians have obtained quinacrine through compounding pharmacies.
Precautionary Information
Adverse Reactions and Side Effects
Side effects are common. Vomiting occurs after oral administration.
Instructions for Use
Doses listed are for treatment of giardiasis. Effects for other organisms are not reported.
Formulations
Quinacrine is available in 100-mg tablets. Quinacrine may no longer be marketed in the US, but it may be available from some pharmacies in a compounded formulation.
Stability and Storage
Store in a tightly closed container, protected from light, and at room temperature. Stability of compounded formulations has not been evaluated.
Regulatory Information
Withdrawal times are not established for animals that produce food. For extralabel use withdrawal interval estimates, contact FARAD at 1-888-USFARAD (1-888-873-2723).
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