Protein-Losing Nephropathy

Protein-Losing Nephropathy



Basic Information image



Definition


A disease of protein loss via the kidney caused by an increase in glomerular permeability



Epidemiology



Risk Factors


Systemic disease usually precedes the development of protein-losing nephropathy.



Associated Conditions and Disorders




• Glomerulonephritis


• Thrombosis caused by renal loss of antithrombin III


• When clinical signs become apparent, renal failure often develops



Clinical Presentation



Disease Forms/Subtypes


May be subclinical or clinical



History, Chief Complaint




• Weight loss


• ± Ventral edema


• ± Anorexia


• ± Lethargy



Physical Exam Findings




• Poor body condition or weight loss


• ± Ventral edema



Etiology and Pathophysiology


Damage to the glomerular membrane allows proteins to leak from systemic circulation into the renal tubules. The protein cannot be reabsorbed, so it is lost via the urine.



Diagnosis image



Differential Diagnosis




• Glomerulonephritis (renal protein loss)


• Amyloidosis (renal protein loss)


• Protein-losing enteropathy (gastrointestinal protein loss)


• Hepatic disease (ill thrift, hypoproteinemia; decreased production of protein)


• Urinary tract infection (bacteriuria or pyuria)

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Jul 24, 2016 | Posted by in SMALL ANIMAL | Comments Off on Protein-Losing Nephropathy

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