16 MYELODYSPLASTIC SYNDROMES
4 List possible functional abnormalities detected in patients with MDS.
In human patients, functional abnormalities have been demonstrated in the hematopoietic cells produced by the abnormal stem cell. Recurrent infections or bleeding tendencies may be seen as a result of abnormal neutrophil or platelet function, respectively. Similar clinical findings have been documented in animals with MDS, although further investigation is necessary to document functional defects. Table 16-1 lists functional abnormalities detected in humans with MDS.
Table 16-1 Functional Abnormalities Documented in Humans with MDS
CELL TYPE | FUNCTIONAL ABNORMALITY |
---|---|
Red cells | |
Neutrophils | |
Platelets |
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