Mast Cell Tumors
Basic Information 
Clinical Presentation
Disease Forms/Subtypes
• Most common as a solitary, soft tissue nodule occurring most frequently on the extremities, head, and neck and less commonly on the trunk. Isolated case reports have identified these tumors in such locations as the nares, nasopharynx, trachea, synovium, trabecular bone of P3, sclera, and nictitating membrane. The mass can be either soft or firm but is loosely attached to the underlying tissues except for those that occur on the distal limb that are hard and firmly attached. The mass generally appears as a subcutaneous nodule covered with skin, although the skin may be ulcerated or alopecic. Most often, the mass is slow growing or static in nature. The lesions are most often benign, although local invasion of surrounding tissues and metastatic disease with invasion of local lymph nodes has been reported.
• A congenital form of generalized mast cell tumor development was reported in a neonatal Quarter Horse foal. The foal developed numerous subcutaneous nodules over the trunk and limbs shortly after birth. The nodules began as small subcutaneous masses but later enlarged and then ulcerated before spontaneous regression. The lesions reappeared cyclically during the horse’s first year of life. This syndrome has been related to urticaria pigmentosa in humans.
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