Lupus Complex Basic Information Definition A multisystemic disease caused by the production of multiple autoantibodies, especially those directed against nucleic acids. It usually involves the skin and at least one other organ. Synonym(s) Systemic lupus erythematosus, SLE Epidemiology Species, Age, Sex Sporadic in onset but rare Clinical Presentation Disease Forms/Subtypes • Generally presents as a generalized skin disease with alopecia, dermal ulceration, and crusting • Antiglobulin-positive anemia • Glomerulonephritis • Nonseptic, nonerosive synovitis • Lymphadenopathy History, Chief Complaint • Extensive skin lesions • Nonspecific lethargy and weakness Etiology and Pathophysiology • This is a complex syndrome that results from major dysregulation of the B-cell system. • It leads to the production of multiple autoantibodies directed against nuclear, cytoplasmic, and cell membrane antigens. • The pathognomonic antibodies are those directed against nucleic acids. Diagnosis The diagnosis of lupus is difficult. As a syndrome, its diagnosis cannot be based on a single diagnostic test but rather on a collection of different lesions and exclusion of other causes Differential Diagnosis • Bacterial or fungal skin diseases • Pemphigus complex< div class='tao-gold-member'> Only gold members can continue reading. Log In or Register to continue Share this:Click to share on Twitter (Opens in new window)Click to share on Facebook (Opens in new window) Related Related posts: Diarrhea, Neonatal Nephrotic Syndrome Staphylococcus Pyoderma Dermatophilosis Stay updated, free articles. Join our Telegram channel Join Tags: Clinical Veterinary Advisor The Horse Jul 24, 2016 | Posted by admin in SMALL ANIMAL | Comments Off on Lupus Complex Full access? Get Clinical Tree
Lupus Complex Basic Information Definition A multisystemic disease caused by the production of multiple autoantibodies, especially those directed against nucleic acids. It usually involves the skin and at least one other organ. Synonym(s) Systemic lupus erythematosus, SLE Epidemiology Species, Age, Sex Sporadic in onset but rare Clinical Presentation Disease Forms/Subtypes • Generally presents as a generalized skin disease with alopecia, dermal ulceration, and crusting • Antiglobulin-positive anemia • Glomerulonephritis • Nonseptic, nonerosive synovitis • Lymphadenopathy History, Chief Complaint • Extensive skin lesions • Nonspecific lethargy and weakness Etiology and Pathophysiology • This is a complex syndrome that results from major dysregulation of the B-cell system. • It leads to the production of multiple autoantibodies directed against nuclear, cytoplasmic, and cell membrane antigens. • The pathognomonic antibodies are those directed against nucleic acids. Diagnosis The diagnosis of lupus is difficult. As a syndrome, its diagnosis cannot be based on a single diagnostic test but rather on a collection of different lesions and exclusion of other causes Differential Diagnosis • Bacterial or fungal skin diseases • Pemphigus complex< div class='tao-gold-member'> Only gold members can continue reading. Log In or Register to continue Share this:Click to share on Twitter (Opens in new window)Click to share on Facebook (Opens in new window) Related Related posts: Diarrhea, Neonatal Nephrotic Syndrome Staphylococcus Pyoderma Dermatophilosis Stay updated, free articles. Join our Telegram channel Join Tags: Clinical Veterinary Advisor The Horse Jul 24, 2016 | Posted by admin in SMALL ANIMAL | Comments Off on Lupus Complex Full access? Get Clinical Tree
