Heinz Bodies Basic Information Definition Heinz bodies are erythrocyte structures composed of precipitated denatured hemoglobin. On Wright’s-stained blood smears, they appear as a rounded structure protruding from the margin of an erythrocyte or as a small somewhat refractile spot within the cell. Synonym(s) Erythrocyte refractile bodies Typical Normal Range (US units; SI units) Rare to absent Physiology Heinz bodies are the result of oxidative damage to erythrocyte hemoglobin. They may be seen in conjunction with eccentrocytes, which are the result of oxidative damage to the erythrocyte membrane. Heinz body formation is a cause of hemolytic anemia. Heinz body hemolytic anemia is usually associated with a toxic exposure, but rare cases may result from hereditary defects in the molecular milieu that acts to protect erythrocytes from oxidative damage (see later). Causes of Abnormally High Levels Heinz body formation in horses has been associated with red maple leaf toxicosis, wild onion toxicosis, and phenothiazine administration. Copper and zinc toxicosis have caused Heinz body formation in other species and might potentially do so in horses. In rare cases, hereditary defects in the mechanisms that act to protect erythrocytes from oxidative damage may result in Heinz body formation. Included here would be deficiencies of glucose-6-phosphate dehydrogenase, flavanone-adenine dinucleotide (FAD), glutathione, or glutathione reductase.< div class='tao-gold-member'> Only gold members can continue reading. Log In or Register to continue Share this:Click to share on Twitter (Opens in new window)Click to share on Facebook (Opens in new window) Related Related posts: Aggressive Stallion Behavior Aflatoxin Toxicosis Biliary Atresia Black Widow Spider Toxicosis Stay updated, free articles. Join our Telegram channel Join Tags: Clinical Veterinary Advisor The Horse Jul 24, 2016 | Posted by admin in SMALL ANIMAL | Comments Off on Heinz Bodies Full access? Get Clinical Tree
Heinz Bodies Basic Information Definition Heinz bodies are erythrocyte structures composed of precipitated denatured hemoglobin. On Wright’s-stained blood smears, they appear as a rounded structure protruding from the margin of an erythrocyte or as a small somewhat refractile spot within the cell. Synonym(s) Erythrocyte refractile bodies Typical Normal Range (US units; SI units) Rare to absent Physiology Heinz bodies are the result of oxidative damage to erythrocyte hemoglobin. They may be seen in conjunction with eccentrocytes, which are the result of oxidative damage to the erythrocyte membrane. Heinz body formation is a cause of hemolytic anemia. Heinz body hemolytic anemia is usually associated with a toxic exposure, but rare cases may result from hereditary defects in the molecular milieu that acts to protect erythrocytes from oxidative damage (see later). Causes of Abnormally High Levels Heinz body formation in horses has been associated with red maple leaf toxicosis, wild onion toxicosis, and phenothiazine administration. Copper and zinc toxicosis have caused Heinz body formation in other species and might potentially do so in horses. In rare cases, hereditary defects in the mechanisms that act to protect erythrocytes from oxidative damage may result in Heinz body formation. Included here would be deficiencies of glucose-6-phosphate dehydrogenase, flavanone-adenine dinucleotide (FAD), glutathione, or glutathione reductase.< div class='tao-gold-member'> Only gold members can continue reading. Log In or Register to continue Share this:Click to share on Twitter (Opens in new window)Click to share on Facebook (Opens in new window) Related Related posts: Aggressive Stallion Behavior Aflatoxin Toxicosis Biliary Atresia Black Widow Spider Toxicosis Stay updated, free articles. Join our Telegram channel Join Tags: Clinical Veterinary Advisor The Horse Jul 24, 2016 | Posted by admin in SMALL ANIMAL | Comments Off on Heinz Bodies Full access? Get Clinical Tree
