Glutamate Dehydrogenase (GLD)

Glutamate Dehydrogenase (GLD)



Basic Information image



Definition


Leakage enzyme: Soluble cytoplasmic enzymes released into circulation after increased membrane permeability (sublethal cellular injury or cellular necrosis)



Typical Normal Range (US units; SI units)


0 to 11.8 IU/L



Physiology


GLD is a mitochondrial enzyme involved in the citric acid cycle and amino acid metabolism that is relatively specific for hepatic disease in the horse. It is leaked after hepatocyte necrosis but not sublethal damage. GLD is most highly concentrated in centrilobular hepatocytes (zone 3) and is most affected by hypoxia and the majority of hepatotoxins.



Causes of Abnormally High Levels




• Marked increases in acute hepatitis (equine herpesvirus type 1), embolic bacterial diseases, Tyzzer’s disease (Clostridium piliformis), hepatotoxins such as pyrrolizidine alkaloids, Theiler’s disease (aka serum hepatitis), and chronic active hepatitis


• Mild increases in cholestasis and hyperlipemia syndrome

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Jul 24, 2016 | Posted by in SMALL ANIMAL | Comments Off on Glutamate Dehydrogenase (GLD)

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