APPENDIX D Antibiotic Drug Selection for Equine Bacterial Pathogens
| Pathogen | Drug Choice | Alternate Choice |
|---|---|---|
| Gram-Positive | ||
| Rhodococcus equi | Erythromycin ± Rifampin; Azithromycin | Clarithromycin |
| Streptococcus spp. | Penicillin G, Ampicillin, Ceftiofur | Trimethoprim-Sulfonamides, Erythromycin, Chloramphenicol |
| Staphylococcus aureus | Trimethoprim/Sulfonamide | Enrofloxacin, Orbifloxacin, Chloramphenicol, Gentamicin |
| Gram-Negative | ||
| Escherichia coli | Gentamicin, Amikacin | Ceftiofur, Enrofloxacin, Orbifloxacin, Marbofloxacin, Trimethoprim/Sulfonamide |
| Klebsiella pneumoniae | Gentamicin, Amikacin | Ceftiofur, Enrofloxacin, Orbifloxacin, Marbofloxacin, Trimethoprim/Sulfonamide |
| Enterobacter spp. | Gentamicin, Amikacin | Ceftiofur, Enrofloxacin, Trimethoprim/Sulfonamide |
| Pseudomonas aeruginosa | Gentamicin, Amikacin, Ticarcillin | Enrofloxacin, Cefepime, Ceftazidime |
| Pasteurella spp. | Ampicillin, Ceftiofur, Trimethoprim/Sulfonamide | Enrofloxacin, Orbifloxacin, Marbofloxacin, Chloramphenicol, Tetracycline |
| Actinobacillus spp. | Ampicillin, Penicillin, Trimethoprim/Sulfonamides | Enrofloxacin, Amikacin, Gentamicin, Ceftiofur |
| Anaerobes | ||
| Clostridium, Fusobacterium, Peptostreptococcus, Bacteroides spp. | Metronidazole, Penicillin G | Chloramphenicol, Cefotetan (injectable) or Cefoxitin (injectable) |
| Other | ||
| Lawsonia intracellularis | Oxytetracycline, Doxycycline (oral only) | Chloramphenicol, Erythromycin, Clarithromycin, Azithromycin |
| Ehrlichia | Oxytetracycline, Doxycycline (oral only) | Chloramphenicol |
| Neorickettsia risticii (Potomac horse fever) | Oxytetracycline, Doxycycline (oral only) | |
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