Disorders of the Ovaries

15 Disorders of the Ovaries




FREQUENTLY ASKED QUESTIONS



1) If I think my dog has a problem with her ovaries, what’s the best way to find out?

Normal ovaries never are palpable in the abdomen and rarely are visible on ultrasound. Ovaries that are enlarged due to presence of cysts or neoplasia may be visible on ultrasound. Most often, ovarian problems are diagnosed by measurement of hormones in blood or by changes in the bitch’s behavior or physical appearance.



I. OVARIAN CYSTS



A. DEVELOPMENT


Two types of ovarian cysts have been described in dogs. The most common is the follicular cyst. This is a follicle that develops to the size commonly seen just before ovulation but that does not ovulate or regress. Follicular cysts persistently produce estrogen from the granulosa cells lining the follicle. These cells do not undergo the normal change to luteal cells and do not produce progesterone. Follicular ovarian cysts may be induced to occur by treatment of the bitch with estrogen, as for pregnancy termination (see Chapter 11).


The less common variety of ovarian cysts in dogs is the luteal cyst. Luteal cysts are structures that form after ovulation like normal corpora lutea but that do not regress at the end of diestrus. Luteal cysts persistently produce progesterone. Luteal cysts must be differentiated from cystic corpora lutea; the latter are normal, functioning corpora lutea that develop a hollow, fluid-filled center. These structures may be seen by ultrasound and should not be confused with a pathologic functional luteal cyst (Figure 15-1).


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Figure 15-1 Ultrasound of normal ovary.



B. SIGNALMENT


There is no breed that is predisposed to formation of ovarian cysts. They can occur in bitches of any age and may be an incidental finding when older bitches are spayed. I tend to treat follicular cysts more commonly in younger bitches than in older bitches; this may be because owners choose to spay bitches with recurrent ovarian cysts at a relatively young age. Effect of previous pregnancy on development of cysts is controversial and has not been defined by research.



C. HISTORY AND CLINICAL SIGNS


The persistent production of estrogen by follicular cysts causes prolonged clinical signs and history of proestrus or estrus with prolonged bloody vulvar discharge and vulvar swelling and attraction of male dogs. The persistent production of progesterone by luteal cysts may cause infertility or prolonged anestrus. Protracted exposure of the uterus to progesterone may predispose bitches to cystic endometrial hyperplasia and pyometra (see Chapter 16). Many ovarian cysts do not produce significant amounts of either estrogen or progesterone, and these cysts presumably do not alter reproductive function of the bitch.



D. DIAGNOSIS


Diagnosis of ovarian cysts requires demonstration of abnormal persistent hormone production or demonstration of a cystic mass at the area of the ovary. Diagnosis of persistent estrogen secretion usually is made with serial vaginal swabs. Even at high concentrations, estrogen is present in the bloodstream in such small amounts that assay for the hormone in serum is difficult. The characteristic change of vaginal epithelial cells from noncornified to cornified under the influence of estrogen, as described for breeding management (see Chapter 9), is a good bioassay for persistent estrogen production. The longest reported time for normal bitches to be in proestrus and estrus, and therefore the longest time that normal bitches should have cornified vaginal epithelial cells, is 40 days. Any bitch documented to have cornified vaginal cytology for longer than 40 days has persistent estrogen secretion. Progesterone is easily assayed in blood. Normal bitches maintain high concentrations of progesterone in the blood for 60 days after estrus; documentation of high progesterone concentrations beyond that time is indicative of persistent progesterone secretion.


Ovarian cysts may become large enough to be palpable in the abdomen or visible by ultrasound. Definitive diagnosis requires surgical removal of a biopsy specimen or an entire ovary and submission to a pathologist. This is an invasive and expensive procedure and may impair the bitch’s future reproductive potential; thus it is not often employed. Response to treatment often is used for diagnosis; if the dog does not respond to treatment for an ovarian cyst, ovarian neoplasia is more likely to be the cause of the problem.



E. TREATMENT


In bitches not intended for breeding or those with a history of reproductive tract disease, ovariohysterectomy (OHE, spay) is the treatment of choice. The ovaries should be submitted to a pathologist to verify that ovarian cystic disease, and not ovarian neoplasia, was the cause of the problem.


In reproductively valuable bitches, follicular cysts are treated by administration of either gonadotropin-releasing hormone (GnRH), which causes release of luteinizing hormone (LH) from the bitch’s pituitary gland and luteinization or ovulation of the follicle, or of human chorionic gonadotropin (hCG), which acts as LH in the bitch’s body, again causing luteinization or ovulation of the follicle. Luteal cysts are treated by administration of the hormone prostaglandin F2α, which causes breakdown of luteal tissue and cessation of progesterone production. All bitches treated medically should be carefully evaluated for cystic endometrial hyperplasia and pyometra, which are more likely to occur after excessive or prolonged exposure of the uterus to estrogen and/or progesterone (see Chapter 16).

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Jul 18, 2016 | Posted by in PHARMACOLOGY, TOXICOLOGY & THERAPEUTICS | Comments Off on Disorders of the Ovaries
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