Creatine Kinase

Creatine Kinase

Definition

Creatine kinase (CK) exists as three isozymes in skeletal muscle, in cardiac muscle, and in the brain. CK is considered to be specific for muscle cell damage and is used primarily for the diagnosis of skeletal muscle injury. CK has a relatively short half-life (<72 hours).

Synonyms

CK, creatine phosphokinase, CPK

Physiology

CK is a magnesium-dependent dimeric enzyme that is responsible for catalyzing the reaction that converts adenosine diphosphate (ADP) and creatine phosphate to adenosine triphosphate (ATP) and creatinine in skeletal, cardiac, and smooth muscle, as well as in the brain. CK is present in the cytosol and mitochondria of myocytes. Therefore, CK is critical for energy production in muscle tissue for contraction. Serum CK activity is primarily of muscle origin. In many species, it is considered a sensitive indicator of skeletal or cardiac muscle damage.

Typical Normal Range

The typical normal range for this laboratory test varies greatly among species. The reader is referred to the following Elsevier publications for additional information:

Carpenter J: Exotic animal formulary, ed 4, St Louis, 2013, Saunders.

Mader D: Reptile medicine and surgery, ed 2, St Louis, 2006, Saunders.

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