Test/isoform
Within-run precision (CV)
Between-run precision (CV)
Linearity (R 2)
Hydragel method
BALP
7.2
8.0
0.99
LALP
9.6
10.8
0.97
CALP
3.7
3.7
0.96
Biochemical method
BALP
4.2
4.2
0.99
LALP
4.8
3.9
0.99
CALP
1.1
1.0
0.99
Simple linear regression models fit to the data demonstrated good correlation (R 2 close to 1) only for BALP (Table 22.2). For the CALP isoform, constant and proportional errors were present. These findings were supported by a Bland–Altman plot (mean bias = 22.6). Deming regression analysis also demonstrated constant and proportional errors for BALP in group C.
Table 22.2
Results of simple linear regression models fit to measurements of ALP isoforms determined by Hydragel and biochemical methods
Isoform | Slope (95% CI) | Intercept (95% CI) | R 2 | Error |
|---|---|---|---|---|
BALP | 0.98 (0.95–1.02) | −4.91 (−10.59–0.76) | 0.99 | No |
LALP | 1.21 (0.54–1.87) | −11.57 (−56.01–32.87) | 0.36 | No |
CALP | 0.39 (−0.04–0.82) | 60.05 (8.89–111.22) | 0.27 | Constant and proportional
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