Basophil (Basophilia, Basopenia)
Basic Information 
Definition
Basophils are granulocytes that originate from the bone marrow. These cells have a lobulated nucleus and contain moderate numbers of basophilic granules.
Physiology
Basophils are the least numerous granulocyte and have functions similar to mast cells. They can release histamine in allergic reactions and type I hypersensitivity responses. They are involved in lipid metabolism via activation of lipoprotein lipase and have less effective antiparasitic activity than eosinophils. They often act in conjunction with eosinophils in performing various functions.
Causes of Abnormally High Levels
Elevations in basophils or basophilia usually accompany an eosinophilia and can be seen with long-standing IgE stimulation such as allergic responses or parasitic infestation. Also, during hyperlipidemic states can result in a basophilia in the absence of an eosinophilia.
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