Anemia, Regenerative

Anemia, Regenerative



Basic Information image



Definition


Anemia is decreased erythrocyte (red blood cell [RBC]) mass, as identified by decreases in hematocrit, hemoglobin, and RBC count. Regenerative anemias are those in which the bone marrow is responding properly in an attempt to correct the anemia and are due to blood loss or hemolysis (premature destruction of RBCs).



Synonym(s)


Responding or responsive anemia.



Typical Normal Range (US Units; SI Units)




• Hematocrit: 27% to 43% (0.27–0.43 L/L)


• Hemoglobin: 10.1 to 16.1 g/dL (101–161 g/L)


• RBC count: 6.0 to 10.4 × 106 /µL (6.0–10.4 × 1012/L)



Physiology


Regenerative anemia occurs due to blood loss or premature destruction of erythrocytes (hemolysis). Decreased tissue oxygenation stimulates erythropoietin production, which stimulates the bone marrow to increase RBC production.



Causes of Abnormally Low Levels




• As stated previously, regenerative anemia occurs due to blood loss or hemolysis.


• Causes of blood loss include traumatic loss, loss to parasites that feed on blood, blood loss into the gastrointestinal or urogenital tracts from bleeding lesions such as tumors or ulcerations, and blood loss due to disorders of hemostasis.


• Causes of hemolytic anemia include immune-mediated destruction of RBCs (including neonatal isoerythrolysis and reaction to an incompatible blood transfusion), oxidative damage to RBCs (eg, red maple leaf, onion, rye grass, Brassica spp, or phenothiazine toxicosis; one known case of glucose-6-phosphate dehydrogenase deficiency), RBC parasitism, severe hypophosphatemia, snake envenomation, hypotonic fluid administration, and RBC fragmentation due to microangiopathy (eg, vasculitis or disseminated intravascular coagulation).

< div class='tao-gold-member'>

Related posts:

  1. Aggressive Stallion Behavior
  2. Aflatoxin Toxicosis
  3. Biliary Atresia
  4. Black Widow Spider Toxicosis

Stay updated, free articles. Join our Telegram channel
Tags:
Jul 24, 2016 | Posted by in SMALL ANIMAL | Comments Off on Anemia, Regenerative

Full access? Get Clinical Tree
Get Clinical Tree app for offline access