DEFINITION/OVERVIEW
- Primary palatal cleft (palatoschisis): located at the junction/suture of the incisive bone and one or both of the maxillary processes; may be associated with cleft lip (cheiloschisis) (Fig. 21-1)
- Secondary palatal cleft: defect on midline behind incisal area involving the soft and/or hard palate
ETIOLOGY/PATHOPHYSIOLOGY
- Dogs/cats
- Failure of the developing paired palatine processes to fuse properly
- As in people, the cause is thought to be multifactorial: contributory risk genes together with environmental influences (teratogen exposure) will result in a cleft defect if a threshold is reached
- In many cases with a wide variety of breeds, there likely has been an intrauterine insult during fetal development
- Teratogens include infectious agents, corticosteroids, excessive vitamin A or D, X-ray radiation, griseofulvin, hormones, and nutritional deficiencies
- In some, genetic predisposition: incomplete penetrance in shih tzu
- Failure of the developing paired palatine processes to fuse properly
SIGNALMENT/HISTORY
- Any breed or gender if intrauterine insult
- Prevalence reported in brachycephalic breeds, beagles, cocker spaniels, dachshunds
- Secondary cleft readily apparent at birth if external cleft lip (cheiloschisis) is present
- Primary cleft: apparent with oral exam that each newborn should receive (Fig. 21-2)
- Newborn may have history of poor nursing, and decreased growth, with milk draining or bubbling from nose
CLINICAL FEATURES
Dogs
- Primary cleft palate
- Unilateral or bilateral cleft at rostral aspect of maxilla
- Often associated with cleft lip
- Seldom has clinical signs unless associated with a secondary cleft palate
- Dental anomalies, such a tooth number, size, and morphology are common in both deciduous and permanent dentition; the maxillary third incisor in the vicinity of the cleft is frequently involved
- Unilateral or bilateral cleft at rostral aspect of maxilla
- Secondary cleft palate
- Midline defect can be mild to extensive, involving hard and/or soft palate
- Unable to nurse effectively without proper suction
- Poor growth, unthrifty
- Milk drainage from nose, gagging, sneezing
- Can progress to rhinitis or even aspiration pneumonia, which can be fatal
- Poor growth, unthrifty
- Midline defect can be mild to extensive, involving hard and/or soft palate
Cats
- Less common than in dogs
DIFFERENTIAL DIAGNOSIS
- Traumatic palatal defects
DIAGNOSTICS
- Complete oral examination: this should be an essential part of every newborn examination
- Intraoral radiograph to assess the extent of osseous involvement (Fig. 21-3)
- Appropriate preoperative diagnostics when indicated prior to procedure